(Last Updated On: 20/04/2021)
Updated March. In September they launched a Phase 1 trial. On Jan. 22 they registered another Phase 2 trial with 4000 volunteers. In December, the Korea Biomedical Review reported that Genexine got disappointing results from their initial formulation and decided to restart their trials with a modified vaccine. They also began testing versions of their vaccine tailored against new variants. ImmunityBio launched a Phase 1 trial of a Covid-19 vaccine in October in the United States and another in South Africa in January. Efficacy: Unknown → If you want to keep up-to-date with on our work on COVID-19, and the many other topics we cover you can sign up to our newsletter. They’ve taken on a number of different diseases this way; their flu vaccine finished Phase 3 clinical trials last March. The spray, called BBV154, contains a chimpanzee adenovirus developed by researchers at Washington University. Updated April 15, PHASE 1 PHASE 2 COMBINED PHASES The company added pieces of coronavirus vaccines to the shells, selected for their potential both to produce antibodies and to train T cells to attack infected cells. Before the pandemic, the Pennsylvania-based company Inovio developed DNA-based vaccines that are delivered into the skin with electric pulses from a hand-held device. Other viral vectors slowly replicate, carrying coronavirus proteins on their surface. Other genetic vaccines in active preclinical development include vaccines from: Applied DNA Sciences, EvviVax and Takis Biotech; DIOSynVax; Elixirgen Therapeutics; ETheRNA; EyeGene; Globe Biotech; Greenlight Biosciences; Infectious Disease Research Institute and Amyris; Mediphage Bioceuticals; National institute of Chemistry of Slovenia and Kemijski Inštitut; National Research Centre, Egypt; the OPENCORONA Consortia; Providence Therapeutics; Scancell; the Spanish National Center for Biotechnology and the Spanish National Research Council; Vaccibody. Emergency use in: India, Iran, Mauritius, Mexico NEW, Nepal, Zimbabwe. In August, Arcturus launched a Phase 1/2 trial at Singapore General Hospital. The European Union began a rolling review in February, intended to speed up approval if the Phase 3 trial delivers positive results. On Dec. 22, the company registered a Phase 1 clinical trial for adults and began recruiting volunteers on Feb. 25. New Jersey is rolling out COVID-19 vaccines in a phased approach to all adults who live, work, or study in the State. On Oct. 25, the Israeli government announced that the vaccine, called Brilife, would be going into a Phase 1 trial. In the spring of 2020, the Israel Institute for Biological Research started work on a coronavirus vaccine based on vesicular stomatitis viruses. Vaccine name: COVAC After expanding its production lines, Sinovac said in April that its manufacturing capacity was up to two billion doses. Storage: Stable in refrigerator The company halted the trial. Type: Skin injection EMERGENCY USE IN U.S., ELSEWHERE Then they manufacture RNA molecules encoding the rewritten genes. Some viral vector vaccines enter cells and cause them to make viral proteins. In addition, it encodes instructions for building small pieces of other viral proteins called nucleocapsid and ORF3a. New York-based Codagenix develops vaccines based on live attenuated viruses, but with a twist: they create the viruses from scratch. Help us do this work by making a donation. On Feb. 24, the F.D.A. The South Korean vaccine company SK Bioscience licensed the vaccine, called GBP510. They deliver virus genes into leaves, and the plant cells then create protein shells that mimic viruses.In July, Medicago launched Phase 1 trials on a plant-based Covid-19 vaccine in combination with adjuvants to boost the immune system’s response to the viral proteins. The DNA is inserted into harmless bacteria, which volunteers swallow in a frozen liquid (the company is working on putting the bacteria into a pill). The researchers also announced that it had a 100 percent efficacy against severe Covid-19. The vaccine used a weakened measles virus that carries a gene for the coronavirus spike protein. Type: Nasal spray In July a Phase 3 trial began in the United Arab Emirates in July, and in Morocco and Peru the following month.On Sept. 14, the U.A.E. The United Kingdom and Argentina were the first countries to give the vaccine emergency authorization, on Dec. 30, and since then a number of other countries have also done the same. in May.On March 11, Novavax reported that their United Kingdom trial determined an efficacy rate of 96 percent against the original coronavirus. Dose: 2 doses, 4 weeks apart A Phase 1 trial began in June 2020 but has yet to produce results. Researchers at Thailand’s Chulalongkorn University have been developing several potential vaccines for the coronavirus. Another combination trial is currently underway between the Oxford-AstraZeneca, Pfizer, Moderna and Novavax vaccines. Approved for use in: Brazil. If they receive the second dose, the metric stays the same. Shipments could begin as soon as the third quarter of 2021.On Nov. 16, 2020, Johnson & Johnson announced that they were also launching a second Phase 3 trial to observe the effects of two doses of their vaccine, instead of just one. Updated March 25. On Dec. 14, the president of the university said that the Phase 1 trial was complete. On Nov. 25, the company reached an agreement with the European Commission to supply up to 160 million doses. PHASE 2 PHASE 3 COMBINED PHASES Type: Muscle injection Tests on animals showed that it protected them against infection. APPROVED IN BRAZIL COVID Vaccine Dashboard Due to ongoing system and data transfer issues that have caused delays in updating the COVID vaccine dashboard every day, the dashboard is temporarily unavailable. They launched a Phase 1/2 trial of the vaccine, named DS-5670, on March 22. gave emergency use authorization for a vaccine made by the Boston-based company Moderna. This data is only available for countries which report the breakdown of doses administered by first and second doses. We are currently vaccinating those who are eligible for vaccination under Pennsylvania’s Phase 1a and 1b. On Nov. 9, the company announced that an interim analysis of the trial showed that the vaccine produced an immune response that’s in the range of responses seen in people who recovered from Covid-19. Last May, they launched a Phase 1 trial on 192 volunteers which indicated the vaccine was safe and produced an immune response. The answer is Because of this, some people wonder if they are safe. Cahill-Keyes map projection by Gene Keyes. In February the company registered a Phase 1 trial of an oral version of the vaccine. Four months after their announcement, South Korean lawmakers said they had foiled an attempt by North Korea to hack South Korean companies developing coronavirus vaccines. Like its other candidates, Soberana Plus targets the part of the coronavirus known as the RBD and contains an adjuvant. Along with their Beijing Institute vaccine, Sinopharm also tested an inactivated virus vaccine developed by the Wuhan Institute of Biological Products. The Trump administration awarded a $1.9 billion contract in July for 100 million doses, but The New York Times reported in December that the administration passed up the chance over the summer to secure another 100 million doses. The Vaccine and Infectious Disease Organization at the University of Saskatchewan has developed a vaccine candidate which uses protein subunits to develop immunity against the coronavirus. The safest way to achieve this is with a vaccine. Cuba’s Finlay Vaccine Institute developed a vaccine known as Soberana 2. Patel also said that the company will initially produce 100 million doses. US state-by-state data: Daily vaccine doses administered per 100 people, Daily number of COVID-19 vaccinations administered, US state-by-state data: Daily vaccine doses administered, US state-by-state data: Administered vaccines per 100 people, US state-by-state data: Total administered vaccines, US state-by-state data: Share that have received at least one dose of the vaccine, US state-by-state data: Number that have received at least one dose of the vaccine, US state-by-state data: Share that have been fully vaccinated against COVID-19, US state-by-state data: Number that have been fully vaccinated against COVID-19, Country-by-country data on COVID-19 vaccinations. Updated April 11, PHASE 3 After partnering with GSK, they launched a Phase 1/2 trial of the vaccine in February. The Chinese company Anhui Zhifei Longcom and the Institute of Medical Biology at the Chinese Academy of Medical Sciences partnered to make a vaccine. This represents the number that have received all doses prescribed by the vaccination protocol. In addition to their Abdala vaccine, the Center for Genetic Engineering and Biotechnology of Cuba announced on Nov. 26 that it was beginning a Phase 1 trial of a second vaccine, this one delivered as a nasal spray. COMBINED PHASES: One way to accelerate vaccine development is to combine phases. Their vaccine Covaxin, made of inactivated coronaviruses, is already in emergency use in India. Updated Sept. 25. Emergency use validation from the World Health Organization. In a March 28 interview, Pankaj Patel, the company’s chairman, said the company expects to have their vaccine ready for distribution by June 2021. On Dec. 22, the company announced a partnership with Pennsylvania-based Ocugen to develop Covaxin for the United States market.On Jan. 3, the Indian government granted Covaxin emergency authorization. Updated March 20, ABANDONED Sanofi and GSK do not expect the vaccine to become available before the end of 2021. Their vaccine can teach the body to develop an immune response against 11 different proteins of the coronavirus. The Massachusetts-based company VBI Vaccines developed a coronavirus vaccine that is based on hollow, virus-like protein shells. Researchers rewrite the genome of viruses, introducing hundreds of mutations. The population estimates we use to calculate per-capita metrics are all based on the last revision of the United Nations World Population Prospects. Storage: Up to two years frozen at –4° F (–20° C), and up to three months refrigerated at 36–46° F (2–8° C). On Dec. 30, Sinopharm announced that the vaccine had an efficacy of 79.34 percent, leading the Chinese government to give it approval. The efficacy determined from the Phase 3 trials has yet to be published. On Nov. 5, Turkey’s Erciyes University announced they had begun injecting volunteers with an inactivated coronavirus vaccine called ERUCOV-VAC. Worried that false positive HIV test results would fuel hesitancy over getting Covid-19 vaccines, the Australian government decided to halt the trial.“It will no longer feature in Australia’s vaccine plan,” said Prime Minister Scott Morrison at a press conference to announce the cancellation. The vaccine developers did not detect any severe side effects in the trial, while observing that the vaccine raised antibodies against the coronavirus as well as other immune defenses. They engineered the viruses to carry the gene for the coronavirus spike protein. They registered a Phase 1 trial in China last November. The researchers commenced a Phase 3 trial In March, Kazakhstan’s vice minister of education and science announced that the vaccine, known as QazVac, was expected to be authorized in April, despite the lack of published results from the Phase 3 trial.The Astana Times reported that 50,000 doses of the vaccine will be available by the end of April. On Dec. 30, Medigen announced that it had received permission to commence a Phase 2 trial. PHASE 3 Additional reporting by Farnaz Fassihi, Denise Grady, Andrew E. Kramer, Matthew Kristoffersen, Hari Kumar, Cao Li, Jess Ruderman and Carlos Tejada. The virus can be safely grown in large quantities in chicken eggs, the same way influenza vaccines have been produced since the 1950s. On Dec. 18, the researchers announced a collaboration with Enesi Pharma to formulate a solid version of the vaccine that can be implanted in the skin without a needle.On Jan. 27, 2021, Robin Shattuck, the leader of the project, announced that “it is not the right time to start a new efficacy trial for a further vaccine in the U.K.” Instead of competing with authorized vaccines, they are turning their efforts to making candidates that will work well emerging variants of the coronavirus. When injected into cells, the vaccine causes them to make spike proteins, which then get released into the body and provoke a response from the immune system. The Serum Institute of India, which licensed the technology from SpyBiotech, is running the trials. The companies launched a Phase 1/2 clinical trial in September.Sanofi’s vaccine was widely expected to play a major role in tackling the pandemic. Additional negotiations have increased the agreement to 300 million doses by July 2021. Moderna has made similar deals with other countries including Canada, Japan, Qatar and South Korea. On Jan. 20, the company registered a Phase 1/2 trial. Updated Dec. 17, PHASE 1 The South Korean company Genexine started testing the safety of a DNA-based vaccine in June 2020. Type: Muscle injection The commission claimed to have tested the vaccine on animals, but provided no data. PHASE 3 Gennova Biopharmaceuticals in India and Seattle-based HDT Bio partnered to develop a vaccine based on self-amplifying RNA. Then they added a gene for the coronavirus spike protein, so that the weakened RSV viruses could present it to the immune system. New Jersey-based OncoSec Immunotherapies has developed experimental cancer treatments that deliver genes into tumors. In an unprecedented move, the Chinese military approved the vaccine on June 25 for a year as a “specially needed drug.” On Nov. 28, the Chief Executive of CanSino Biologics said in an interview that about 40,000 to 50,000 people had received Convidecia.Starting in August 2020, CanSino began running Phase 3 trials in a number of countries, including Pakistan, Russia, Mexico and Chile. And on April 1, Dr. Anthony S. Fauci, the nation’s top infectious disease expert, said that the United States may not need the AstraZeneca vaccine at all.Meanwhile, AstraZeneca and Oxford are continuing research on the vaccine. The 1st dose of the COVID-19 vaccine should give you good protection from coronavirus from 3 or 4 weeks after you've had it. In July, researchers at West China Hospital of Sichuan University published a study in Nature describing a vaccine made from the RBD region of the spike protein that could protect mice and monkeys from the coronavirus. Type: Muscle injection In February 2021, as concerns grew about new mutations in the coronavirus, Chinese researchers tested BBIBP-CorV against a variant called B.1.351, which was first found in South Africa. On Dec. 2, Moderna registered a trial to test the vaccine on adolescents between 12 and 18 years of age. Two days later, the United States followed suit.South Africa dropped plans to use AstraZeneca’s vaccine for their health care workers after a small trial failed to show it was effective against the B.1.351 variant that had grown dominant across the country. Bharat said that they would update their estimate of Covaxin’s efficacy up to 130 cases. Of the first 43 volunteers to get Covid-19, only 7 had received the vaccine. COVID-eVax can remain stable at room temperature. It contains a part of the coronavirus spike protein, fused to a standard tetanus vaccine to make it stable. 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